各位老師同仁及同學您好：

資工系白敦文老師邀請澳大利亞拉籌伯大學Phoebe Y. CHEN教授(Department of Computer Science and Information Technology, La Trobe University, Australia)蒞校訪問並進行專題演講(個人簡歷請參閱連結)，敬邀各位老師同仁及同學踴躍參加！！演講資訊請參考如下：

演講人：Phoebe Y. CHEN教授

服務單位：澳大利亞拉籌伯大學

演講題目：Widespread splicing changes in brain development and aging

演講時間：104年11月11日(三)上午10:30(原定於11月9日下午，因故更改演講時間)

演講地點：電機二館 資工系305室(更改演講地點)

演講內容摘要：While splicing differences between tissues, sexes and species are well documented, little is known about the extent and the nature of splicing changes that take place during human or mammalian development and aging. Here, using high‐throughput transcriptome sequencing, we have characterized splicing changes that take place during whole human lifespan in two brain regions: prefrontal cortex and cerebellum. Identified changes were confirmed using independent human and rhesus macaque RNA‐seq data sets, exon arrays and PCR, and were detected at the protein level using mass spectrometry. Splicing changes across lifespan were abundant in both of the brain regions studied, affecting more than a third of the genes expressed in the human brain. This talk will focus on a widespread of splicing changes in brain development and aging.

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